CAR T Cell Adoptive Therapies: Product Engineering to Clinical Outcomes
Adoptive cell transfer involves the collection, modification and return of a patient’s immune cells, offering a promising immunotherapeutic approach for the treatment of different types of cancers. T cells can be genetically engineered to produce artificial T cell receptors on their surface called chimeric antigen receptors, or CARs. CARs are proteins that allow T cells to recognize a specific protein, or antigen, found on tumor cells. CAR T cells can be cultured and expanded in the laboratory, then re-infused to patients. Through the guidance of the engineered T cell receptor, CAR T cells recognize and destroy the cancer cells that display the specific antigen on their surfaces. Different methods have been used to engineer CAR T cells to improve their potency and effectiveness. This workshop, developed through collaboration with the University of Pennsylvania, will provide an introduction to T cell receptors, CAR T cell applications, CAR T cell manufacture for clinical use, CAR technologies, needs of future therapeutic modalities and regulatory hurdles.
At the end of this workshop, attendees will be able to:
Describe T cell receptors and CAR T cells.
Identify clinical applications of CAR T cells and their outcomes.
Recognize manufacturing technologies and facility considerations.
Describe regulatory hurdles in cellular therapy trials.
Assess technologies and consider needs of future modalities.
Speakers
Catherine Bollard, MBChB, MD
Laurence J. Cooper, MD, PhD
Stephan Grupp, MD, PhD
Carl H. June, MD
Naynesh Kamani, MD
Bruce Levine, PhD
Marcela Maus, MD, PhD
Don Siegel, MD, PhD
Yongping Wang, MD, PhD
Device Panel Speakers
Nancy Johansen
Kim Nguyen, PhD
Phil Vanek
Juan F. Vera, MD
Intended Audience
Individuals interested in new immunotherapies, cell expansion and immunomodulatory effects of targeted cell therapies including professionals in:
Academic and commercial cell therapy facilities
Pharma and biotech companies
Contract manufacturing facilities
Researchers
Suppliers of cellular therapy services and products
For more information about this workshop, please visit www.aabb.org/ctworkshop or contact the Education and Professional Development Department at professionaldevelopment@aabb.org.
