Advancing Innovation During COVID-19


ARM Global Regenerative & Advanced Therapy Medicine Sector Report: H1 2020

Despite the unprecedented global challenge presented by COVID-19, the regenerative medicine and advanced therapy sector demonstrated remarkable resilience in the first half of 2020. Patients continued to benefit from the cell and gene therapies currently on the market and in trials, and investment in the sector was robust. Policymakers and regulators recognize the need to continue to promote development for durable and potentially curative therapies for patients with unmet medical needs outside of COVID-19, though challenges remain. The H1 report provides an overview of the current financial, clinical, and policy landscape for these innovative treatments, with commentary from leading experts on the sector.


ARM Global Regenerative & Advanced Therapy Medicine Sector Report: H1 2020

Despite the unprecedented global challenge presented by COVID-19, the regenerative medicine and advanced therapy sector demonstrated remarkable resilience in the first half of 2020. Patients continued to benefit from the cell and gene therapies currently on the market and in trials, and investment in the sector was robust. Policymakers and regulators recognize the need to continue to promote development for durable and potentially curative therapies for patients with unmet medical needs outside of COVID-19, though challenges remain. The H1 report provides an overview of the current financial, clinical, and policy landscape for these innovative treatments, with commentary from leading experts on the sector.

Global Landscape

1,001+

Regenerative Medicine Companies
Worldwide, Including Gene and
Cell Therapies, and Tissue Engineering
Therapeutic Developers

543North America22Oceania1Africa184Asia13South America238Europe & Israel

Financings

The amount raised in 2020 is on track to surpass that raised in 2018 – the strongest year for sector financings on record.

Total Global Financing

$10.7 Billion

120% YoY from H1 2019

Gene & Gene-modified
Cell Therapy

$7.9 Billion

81% YoY from H1 2019

Cell Therapy

$7.5 Billion

387% YoY from H1 2019

Tissue Engineering

$84 Million

25% YoY from H1 2019

Total Global Financings by Type

141740231615303439756224381493425887619274715157832521238IPOsFollow-OnsCorporatePartnershipsVenture CapitalPrivatePlacement /PIPES0$500m$1,000m$1,500m$2,000m$2,500m$3,000m$3,500m$4,000m$4,500m$5,000m$5,500m$6,000mH1 2020Full Year 2019Full Year 2018
34171128018945Mergers &Acquisitions0$2,000m$4,000m$6,000m$8,000m$10,000m$12,000m$14,000m$16,000m$18,000m$20,000m$22,000m$24,000mH1 2020Full Year 2019Full Year 2018
1,078

regenerative medicine & advanced therapy

clinical trials ongoing worldwide as of the

end of H1 2020

36.5%54.5%9.0%050100150200250300350400450500550600Phase 1Phase 2Phase 3

Number of Clinical Trials Utilizing Specific
RM / AT Technology:

H1 2020

Gene Therapy
30.4%59.9%9.7%020406080100120140160180200220Phase IPhase IIPhase III
Cell-Based Immuno-Oncology
48.8%47.8%0020406080100120140160180200220240Phase IPhase IIPhase III
Cell Therapy
24.0%61.3%14.7%030405060708090100110120130Phase IPhase IIPhase III
Tissue Engineering
13.6%50.0%36.4%06810121416182022Phase IPhase IIPhase III

Clinical Trials by Indication: H1 2020

Oncology
665
Musculoskeletal
58
Endocrine, Metabolic, and Genetic Disorders
55
Central Nervous System
52
Cardiovascular
45
Hematology
37
Ophthalmology
35
Infectious Diseases
33
Immunology & Inflammation
30
Dermatology
22
Gastroenterology
17
Genitourinary Disorders
14
Respiratory
10
Geriatric Diseases
3
Lymphatic Disease
2